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Article

Genetic Predisposition to MASLD: Potential for Therapeutic Management.

International journal of molecular sciences - 18 Feb 2026

Karapanagiotidi Fani, Boutari Chrysoula, Sinakos Emmanouil

Abstract excerpt

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is now the most common liver disease worldwide, with a continuously increasing prevalence. The mechanisms involved in its pathophysiology are numerous and may include metabolic, environmental, and genetic factors. Genome-wide association studies have identified key genetic variants, most notably in PNPLA3, TM6SF2, MBOAT7, GCKR, and HSD17B13. This...

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Topics

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Share to 17-Hydroxysteroid Dehydrogenases
Share to Acyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Adaptor Proteins, Signal Transducing

Share to Fatty Liver

Share to Lipase

Share to Membrane Proteins

Share to Non-alcoholic Fatty Liver Disease

Share to Phospholipases A2, Calcium-Independent

Source

Open in PubMed Open full text

Identifiers

PMID: 41752069
DOI: 10.3390/ijms27041933
PMCID: PMC12940723

Genes

GCKR
HSD17B13
MBOAT7
PNPLA3
TM6SF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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