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CD8+ T Cell-Derived Perforin Exacerbates Dysbiosis and Inflammatory Bowel Disease via β-Hydroxybutyrate Suppression in Mouse Colonic Epithelium

1 May 2025

Abstract excerpt

Background: The etiology and pathogenesis of inflammatory bowel disease (IBD) are generally thought to be related to immune dysfunction and intestinal microbiota dysbiosis. However, the exact mechanisms remain unclear. Methods: We applied a DSS-induced colitis model in wild-type and perforin-deficient ( Prf1−/− ) mice. Adoptive transfer experiments and metabolic profiling were conducted, and 16S rRNA gene...

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PMID: 40331160
DOI: 10.2147/jir.s509875

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