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Microbiota-derived IPA alleviates intestinal mucosal inflammation through upregulating Th1/Th17 cell apoptosis in inflammatory bowel disease

16 Feb 2025

Abstract excerpt

The gut microbiota-derived metabolite indole-3-propionic acid (IPA) plays an important role in maintaining intestinal mucosal homeostasis, while the molecular mechanisms underlying IPA regulation on mucosal CD4+ T cell functions in inflammatory bowel disease (IBD) remain elusive. Here we investigated the roles of IPA in modulating mucosal CD4+ T cells and its therapeutic potential in treatment of human IBD....

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PMID: 39956891
DOI: 10.1080/19490976.2025.2467235

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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