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Kynurenine pathway in Parkinson's disease—An update

9 Sept 2020

Abstract excerpt

Parkinson's disease (PD) is a complex multi-factorial neurodegenerative disorder where various altered metabolic pathways contribute to the progression of the disease. Tryptophan (TRP) is a major precursor in kynurenine pathway (KP) and it has been discussed in various in vitro studies that the metabolites quinolinic acid (QUIN) causes neurotoxicity and kynurenic acid (KYNA) acts as neuroprotectant respectively....

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PMID: 33134567
DOI: 10.1016/j.ensci.2020.100270

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