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Age‐ and disease‐specific changes of the kynurenine pathway in Parkinson’s and Alzheimer’s disease

3 Aug 2019

Abstract excerpt

The kynurenine (Kyn) pathway, which regulates neuroinflammation and N-methyl-d-aspartate receptor activation, is implicated in Parkinson's disease (PD) and Alzheimer's disease (AD). Age-related changes in Kyn metabolism and altered cerebral Kyn uptake along large neutral amino acid transporters, could contribute to these diseases. To gain further insight into the role and prognostic potential of the Kyn pathway...

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PMID: 31376341
DOI: 10.1111/jnc.14843

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