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Article

Mtg16 NHR1 mutations cause defects in lymphopoiesis and the response to anemia.

Experimental hematology - 1 Jul 2025

Bomber Monica, Acharya Pankaj, Johnson Anna E, Sampathi Shilpa, Flaherty David K, Matlock Brittany K, Ellis Jacob D, Bartlett Luke N, Williams Christopher S, Hiebert Scott W, Stengel Kristy R

Abstract excerpt

The Eight-Twenty-One (ETO)/Myeloid Translocation Gene (MTG) family of transcriptional corepressors play a key role in adult stem cell function across multiple tissues and may be affected by mutation, deletion, or translocation in solid tumors and leukemia. Structural studies of the first conserved domain identified residues that make specific contacts with E proteins, such as HEB and E2A. We generated mice with a...

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Identifiers

PMID: 40316246
DOI: 10.1016/j.exphem.2025.104793
PMCID: PMC12221787

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