Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CBFbeta is critical for AML1-ETO and TEL-AML1 activity.

Blood - 26 Mar 2009

Roudaia Liya, Cheney Matthew D, Manuylova Ekaterina, Chen Wei, Morrow Michelle, Park Sangho, Lee Chung-Tsai, Kaur Prabhjot, Williams Owen, Bushweller John H, Speck Nancy A

Abstract excerpt

AML1-ETO and TEL-AML1 are chimeric proteins resulting from the t(8;21)(q22;q22) in acute myeloid leukemia, and the t(12;21)(p13;q22) in pre-B-cell leukemia, respectively. The Runt domain of AML1 in both proteins mediates DNA binding and heterodimerization with the core binding factor beta (CBFbeta) subunit. To determine whether CBFbeta is required for AML1-ETO and TEL-AML1 activity, we introduced amino acid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Differentiation
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Core Binding Factor Alpha 2 Subunit

Share to Granulocytes

Share to NIH 3T3 Cells

Share to Oncogene Proteins, Fusion

Share to RUNX1 Translocation Partner 1 Protein

Share to Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 19179469
DOI: 10.1182/blood-2008-03-147207
PMCID: PMC2662647

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CBFbeta is critical for AML1-ETO and TEL-AML1 activity.PMID 19179469Read ↗

Role of AML1/Runx1 in the pathogenesis of hematological malignanciesSemantic proximity Read ↗

Mammalian runt‐domain proteins and their roles in hematopoiesis, osteogenesis, and leukemiaSemantic proximity Read ↗

The role of a Runt domain transcription factor AML1/RUNX1 in leukemogenesis and its clinical implicationsSemantic proximity Read ↗

A tool compound targeting the core binding factor Runt domain to disrupt binding to CBFβ in leukemic cellsSemantic proximity Read ↗

Proleukemic RUNX1 and CBFbeta mutations in the pathogenesis of acute leukemia.Semantic proximity Read ↗

RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesisSemantic proximity Read ↗

Advances in molecular genetics and treatment of core-binding factor acute myeloid leukemiaSemantic proximity Read ↗

AML1, AML2, and AML3, the Human Members of the runt domain Gene-Family: cDNA Structure, Expression, and Chromosomal LocalizationSemantic proximity Read ↗

The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity.Semantic proximity Read ↗

The core-binding factor leukemias: lessons learned from murine models.Semantic proximity Read ↗

Inhibition of the Transforming Growth Factor β1 Signaling Pathway by the AML1/ETO Leukemia-associated Fusion ProteinSemantic proximity Read ↗

Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.