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The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL -fusion partner in acute myelogeneous leukemia

3 Jul 2001

Abstract excerpt

We have cloned a fusion partner of the MLL gene at 11q23 and identified it as the gene encoding the human formin-binding protein 17, FBP17. It maps to chromosome 9q34 centromeric to ABL. The gene fusion results from a complex chromosome rearrangement that was resolved by fluorescence in situ hybridization with various probes on chromosomes 9 and 11 as an ins(11;9)(q23;q34)inv(11)(q13q23). The rearrangement...

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PMID: 11438682
DOI: 10.1073/pnas.121433898

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