Article
Comparison of circulating immune signatures across different consensus molecular subtypes (CMS) and between left- and right-sided lesions in stage II colorectal cancer using single-cell mass cytometry.
Journal of translational medicine - 1 May 2025
Gao Pin, Zhou Chuanyong, Yang Hong, Deng Shunyu, Jiang Beihai, Wang Zaozao, Di Jiabo, Su Xiangqian
Abstract excerpt
BACKGROUND: Patients with stage II colorectal cancer (CRC) show considerable variability in prognosis. Circulating immune cells play a vital role in systemic tumor surveillance. This study aimed to determine the clinical significance of the frequency and phenotype of circulating immune cell subsets in patients with stage II CRC. METHODS: We applied a 37-marker-cell-lineage-agnostic panel to perform single-cell...
Read the complete abstract on PubMedTopics
- Humans
- Colorectal Neoplasms
- Female
- Neoplasm Staging
- Male
- Single-Cell Analysis