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Resolving the difference between left-sided and right-sided colorectal cancer by single-cell sequencing

18 Nov 2021

Abstract excerpt

Colorectal cancers (CRCs) exhibit differences in incidence, pathogenesis, molecular pathways, and outcome depending on the location of the tumor. The transcriptomes of 27,927 single human CRC cells from 3 left-sided and 3 right-sided CRC patients were profiled by single-cell RNA-Seq (scRNA-Seq). Right-sided CRC harbors a significant proportion of exhausted CD8+ T cells of a highly migratory nature. One cluster of...

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PMID: 34793335
DOI: 10.1172/jci.insight.152616

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