Article
Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jan 2014
Kang Wonchull, Hong Se Hoon, Lee Hye Min, Kim Na Yeon, Lim Yun Chan, Le Le Thi My, Lim Bitna, Kim Hyun Chul, Kim Tae Yeon, Ashida Hiroki, Yokota Akiho, Hah Sang Soo, Chun Keun Ho, Jung Yong-Keun, Yang Jin Kuk
Abstract excerpt
APIP, Apaf-1 interacting protein, has been known to inhibit two main types of programmed cell death, apoptosis and pyroptosis, and was recently found to be associated with cancers and inflammatory diseases. Distinct from its inhibitory role in cell death, APIP was also shown to act as a 5-methylthioribulose-1-phosphate dehydratase, or MtnB, in the methionine salvage pathway. Here we report the structural and...
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