Article
Cell cycle duration determines oncogenic transformation capacity.
Nature - 1 May 2025
Chen Danian, Lu Suying, Huang Katherine, Pearson Joel D, Pacal Marek, Peidis Phillipos, McCurdy Sean, Yu Tao, Sangwan Monika, Nguyen Angela, Monnier Philippe P, Schramek Daniel, Zhu Liang, Santamaria David, Barbacid Mariano, Akeno Nagako, Wikenheiser-Brokamp Kathryn A, Bremner Rod
Abstract excerpt
Oncogenic mutations are widespread in normal human tissues1. Similarly, in murine chimeras, cells carrying an oncogenic lesion contribute normal cells to adult tissues without causing cancer2-4. How lineages that escape cancer via normal development differ from the minority that succumb is unclear. Tumours exhibit characteristic cancer hallmarks; we therefore searched for hallmarks that differentiate cancer-prone...
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