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Article

The role of AdhE on ethanol tolerance and production in Clostridium thermocellum.

The Journal of biological chemistry - 1 Aug 2024

Pech-Canul Angel, Hammer Sarah K, Ziegler Samantha J, Richardson Isaiah D, Sharma Bishal D, Maloney Marybeth I, Bomble Yannick J, Lynd Lee R, Olson Daniel G

Abstract excerpt

Many anaerobic microorganisms use the bifunctional aldehyde and alcohol dehydrogenase enzyme, AdhE, to produce ethanol. One such organism is Clostridium thermocellum, which is of interest for cellulosic biofuel production. In the course of engineering this organism for improved ethanol tolerance and production, we observed that AdhE was a frequent target of mutations. Here, we characterized those mutations to...

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Identifiers

PMID: 39002679
DOI: 10.1016/j.jbc.2024.107559
PMCID: PMC11365378

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