Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

VAV2 exists in extrachromosomal circular DNA and contributes Enzalutamide resistance of prostate cancer via stabilization of AR/ARv7

9 Apr 2025

Abstract excerpt

Extrachromosomal circular DNAs (eccDNAs) are circular, double-stranded DNA molecules ubiquitously present across various organisms, playing a critical role in tumorigenesis and tumor progression. However, their precise contribution to prostate cancer (PCa) remains incompletely understood. To elucidate the function of eccDNAs in PCa, eccDNA sequencing and annotation were performed in PCa tissues and cell lines...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Genetic factors in colorectal cancer
Share to Prostate Cancer Treatment and Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40303312
DOI: 10.7150/ijbs.109271

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

VAV2 exists in extrachromosomal circular DNA and contributes Enzalutamide resistance of prostate cancer via stabilization of AR/ARv7PMID 40303312Read ↗

A Guide to Extrachromosomal DNA: Cancer’s Dynamic Circular GenomeSemantic proximity Read ↗

eccDNAdb: a database of extrachromosomal circular DNA profiles in human cancersSemantic proximity Read ↗

Extrachromosomal circular DNA (eccDNA): from carcinogenesis to drug resistanceSemantic proximity Read ↗

Extrachromosomal circular DNA in cancer: history, current knowledge, and methodsSemantic proximity Read ↗

The urinary eccDNA landscape in prostate cancer reveals associations with genome instability and vital roles in cancer progression.Semantic proximity Read ↗

Exploring the potential of extrachromosomal DNA as a novel oncogenic driver.Semantic proximity Read ↗

Circular RNA circHIPK3 modulates prostate cancer progression via targeting miR-448/MTDH signalingSemantic proximity Read ↗

Classification of extrachromosomal circular DNA with a focus on the role of extrachromosomal DNA (ecDNA) in tumor heterogeneity and progressionSemantic proximity Read ↗

Extrachromosomal circular DNA: biogenesis, structure, functions and diseasesSemantic proximity Read ↗

scEccDNAdb: an integrated single-cell eccDNA resource for human and mouseSemantic proximity Read ↗

EccBase: A high-quality database for exploration and characterization of extrachromosomal circular DNAs in cancerSemantic proximity Read ↗

Extrachromosomal Circular DNA: A New Target in CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.