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Article

Breast Cancer Risk Modification in Women with Pathogenic Variants in BRCA1, BRCA2, ATM, CHEK2, and PALB2.

Cancer research communications - 1 May 2025

Kurian Allison W, Hughes Elisha, Bernhisel Ryan, Hu Eudora, Polley Eric C, Yadav Siddhartha, Hu Chunling, Caswell-Jin Jennifer L, John Esther M, Shadyab Aladdin H, Chlebowski Rowan, Nassir Rami, Kraft Peter, Stefanick Marcia L, Couch Fergus J

Abstract excerpt

SIGNIFICANCE: There is limited information on whether established risk factors increase breast cancer risk from PVs. In the WHI, PV carriers had no substantial (≥2-fold) increase with most risk factors, except potentially MHT in ATM or CHEK2 carriers. The results may inform counseling and research on MHT.

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Source

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Identifiers

PMID: 40298171
DOI: 10.1158/2767-9764.CRC-24-0592
PMCID: PMC12067184

Genes

ATM
CHEK2
BRCA1
BRCA2
PALB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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