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Article

Breast, Colorectal, and Pancreatic Cancer Mortality With Pathogenic Variants in ATM, CHEK2, or PALB2.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 May 2025

Veenstra Christine M, Abrahamse Paul, Hamilton Ann S, Ward Kevin C, Gomez Scarlett L, Liu Lihua, Katz Steven J, Hofer Timothy P, Kurian Allison W

Abstract excerpt

PURPOSE: Oncologists encounter patients with pathogenic variants (PVs) in ATM, CHEK2, or PALB2, but little is known about their cancer mortality. METHODS: Patients who were 20 years or older, diagnosed in 2013-2019 with breast, colorectal, or pancreatic cancer, and reported to SEER registries in California and Georgia were linked to germline genetic testing results from four clinical laboratories and followed...

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Source

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Identifiers

PMID: 40020204
DOI: 10.1200/JCO-24-02442
PMCID: PMC12037317

Genes

ATM
CHEK2
PALB2
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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