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Article

The role of genetic diversity, epigenetic regulation, and sex-based differences in HIV cure research: a comprehensive review.

Epigenetics & chromatin - 3 Jan 2025

Letchumanan Punitha, Theva Das Kumitaa

Abstract excerpt

Despite significant advances in HIV treatment, a definitive cure remains elusive. The first-in-human clinical trial of Excision BioTherapeutics' CRISPR-based HIV cure, EBT-101, demonstrated safety but failed to prevent viral rebound. These outcomes may result from the interplay of several factors. Growing evidence indicates that intricate epigenetic modifications play a major role in the persistence of HIV...

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Epigenesis, Genetic
Genetic Variation
HIV-1
HIV Infections
HIV Research and Treatment

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Identifiers

PMID: 39754177
DOI: 10.1186/s13072-024-00564-4
PMCID: PMC11697457

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