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Biosynthesis and Fatty Acid- and Cation-Binding Properties of Mycobacterium tuberculosis Methylglucose Lipopolysaccharides.

ACS infectious diseases - 9 May 2025

Grzegorzewicz Anna E, Bui Duong T, De Prithwiraj, Kitova Elena N, Belardinelli Juan M, Angala Shiva Kumar, Palčeková Zuzana, Vill Kristin, Kalscheuer Rainer, Klassen John S, Jackson Mary

Abstract excerpt

Methylglucose lipopolysaccharides (MGLPs) are small cytoplasmic polysaccharides produced by mycobacteria and a few Nocardia species. Although their ability to form 1:1 complexes with long-chain fatty acids and acyl-CoAs in vitro has long suggested that they play a role in fatty acid and lipid metabolism, direct evidence for this assumption has been waiting for the availability of mutants with well-defined MGLP...

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PMID: 40295170
DOI: 10.1021/acsinfecdis.4c00883
PMCID: PMC12715691

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