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Article

Prognostic value of KRAS and BRAF mutations in curatively resected colorectal cancer.

World journal of gastroenterology - 28 Jan 2015

Kadowaki Shigenori, Kakuta Miho, Takahashi Shuhei, Takahashi Akemi, Arai Yoshiko, Nishimura Yoji, Yatsuoka Toshimasa, Ooki Akira, Yamaguchi Kensei, Matsuo Keitaro, Muro Kei, Akagi Kiwamu

Abstract excerpt

AIM: To investigate the prognostic role of KRAS and BRAF mutations after adjustment for microsatellite instability (MSI) status in Japanese colorectal cancer (CRC) population. METHODS: We assessed KRAS and BRAF mutations and MSI status in 813 Japanese patients with curatively resected, stage I-III CRC and examined associations of these mutations with disease-free survival (DFS) and overall survival (OS) using...

Topics

Aged
Asian People
Biomarkers, Tumor
Colectomy
Colorectal Neoplasms
Disease-Free Survival
Female
Gene Frequency
Genetic Predisposition to Disease
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Japan

Kaplan-Meier Estimate

Male

Microsatellite Instability

Middle Aged

Multivariate Analysis

Mutation

Neoplasm Staging

Source

Open in PubMed Open full text

Identifiers

PMID: 25632202
DOI: 10.3748/wjg.v21.i4.1275
PMCID: PMC4306173

Genes

BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-25632202-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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