Article

Neuropilin 1 sequestration by neuropathogenic mutant glycyl-tRNA synthetase is permissive to vascular development and homeostasis

2016-10-17

Abstract excerpt

It remains a mystery how dominantly inherited mutations in the housekeeping gene GARS , which encodes glycyl-tRNA synthetase (GlyRS), mediate selective peripheral nerve toxicity resulting in the currently incurable Charcot-Marie-Tooth disease type 2D (CMT2D). A recent study identified the transmembrane receptor protein neuropilin 1 (Nrp1) as a substrate for aberrant extracellular binding of mutant GlyRS. Formatio...

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Literature Corpus work: afa794e8-0138-50b0-8f15-dc438735bacf
DOI: 10.1101/081513

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