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Article

Balancing Anti-Inflammation and Neurorepair: The Role of Mineralocorticoid Receptor in Regulating Microglial Phenotype Switching After Traumatic Brain Injury.

CNS neuroscience & therapeutics - 1 Apr 2025

Zhang Bin, Bai Miao, Yang Mengshi, Wang Yumei, Zhang Xueling, Chen Xiyu, Gao Min, Liu Baiyun, Shi Guangzhi

Abstract excerpt

BACKGROUND: As potent anti-inflammatory agents, glucocorticoids (GCs) have been widely used in the treatment of traumatic brain injury (TBI). However, their use remains controversial. Our previous study indicated that although dexamethasone (DEX) exerted anti-inflammatory effects and protected the blood-brain barrier (BBB) by activating the glucocorticoid receptor (GR) after TBI, it also impeded tissue repair...

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Share to Anti-Inflammatory Agents
Share to Brain Injuries, Traumatic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

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Share to Phenotype

Share to Receptors, Mineralocorticoid

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Identifiers

PMID: 40277259
DOI: 10.1111/cns.70404
PMCID: PMC12023002

Genes

STAT6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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