Article
Tailoring Endometrial Cancer Treatment Based on Molecular Pathology: Current Status and Possible Impacts on Systemic and Local Treatment.
International journal of molecular sciences - 15 Jul 2024
Ribeiro-Santos Pedro, Martins Vieira Carolina, Viana Veloso Gilson Gabriel, Vieira Giannecchini Giovanna, Parenza Arenhardt Martina, Müller Gomes Larissa, Zanuncio Pedro, Silva Brandão Flávio, Nogueira-Rodrigues Angélica
Abstract excerpt
Endometrial cancer (EC) is a heterogeneous disease with a rising incidence worldwide. The understanding of its molecular pathways has evolved substantially since The Cancer Genome Atlas (TCGA) stratified endometrial cancer into four subgroups regarding molecular features: POLE ultra-mutated, microsatellite instability (MSI) hypermutated, copy-number high with TP53 mutations, and copy-number low with...
Topics
- Humans
- Endometrial Neoplasms
- Female
- Microsatellite Instability
- Biomarkers, Tumor
- Mutation
- Pathology, Molecular
- Prognosis
- Tumor Suppressor Protein p53