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Article

Genetic Variations in GCKR and PNPLA3 Regulate Metabolic Balance Across the Liver

24 Apr 2025

Abstract excerpt

We tested genetic variants in GCK, GCKR, and PNPLA3 in a large sample of self-identified Mexican Americans from the BetaGene Study for association with type 2 diabetes-related phenotypes under the hypothesis that they may regulate metabolic balance across the liver and contribute to hepatic steatosis and insulin resistance. We further tested whether interactions with dietary fructose and total sugar contributes...

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Identifiers

PMID: 40272879
DOI: 10.2337/db24-0923

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