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Article

Estimating the Effect of Liver and Pancreas Volume and Fat Content on Risk of Diabetes: A Mendelian Randomization Study.

Diabetes care - 1 Feb 2022

Martin Susan, Sorokin Elena P, Thomas E Louise, Sattar Naveed, Cule Madeleine, Bell Jimmy D, Yaghootkar Hanieh

Abstract excerpt

OBJECTIVE: Fat content and volume of liver and pancreas are associated with risk of diabetes in observational studies; whether these associations are causal is unknown. We conducted a Mendelian randomization (MR) study to examine causality of such associations. RESEARCH DESIGN AND METHODS: We used genetic variants associated (P < 5 × 10-8) with the exposures (liver and pancreas volume and fat content) using MRI...

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Share to Diabetes Mellitus, Type 2
Share to Genetic Associations and Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mendelian Randomization Analysis

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Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 34983059
DOI: 10.2337/dc21-1262

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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