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Article

Insulin resistance is an integral feature of MASLD even in the presence of PNPLA3 variants

6 Apr 2024

Abstract excerpt

Background & Aims It has been postulated that I148M carriers of PNPLA3 (CG[Ile/Met] or GG[Met/Met]) develop MASLD in the absence of insulin resistance or metabolic syndrome. However, the relationship between insulin resistance and MASLD according to PNPLA3 allele has not been carefully assessed. Approach & Results A total of 204 participants were recruited and underwent PNPLA3 genotyping, an oral glucose...

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PMID: 39022386
DOI: 10.1016/j.jhepr.2024.101092

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