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Article

Thin filament mutations: developing an integrative approach to a complex disorder.

Circulation research - 18 Mar 2011

Tardiff Jil C

Abstract excerpt

Sixteen years ago, mutations in cardiac troponin (Tn)T and α-tropomyosin were linked to familial hypertrophic cardiomyopathy, thus transforming the disorder from a disease of the β-myosin heavy chain to a disease of the cardiac sarcomere. From the outset, studies suggested that mutations in the regulatory thin filament caused a complex, heterogeneous pattern of ventricular remodeling with wide variations in...

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Source

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Identifiers

PMID: 21415410
DOI: 10.1161/CIRCRESAHA.110.224170
PMCID: PMC3075069

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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