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Article

Increased inflammatory signature in myeloid cells of non-small cell lung cancer patients with high clonal hematopoiesis burden.

eLife - 6 Dec 2024

Sim Hyungtai, Park Hyun Jung, Park Geun-Ho, Kim Yeon Jeong, Park Woong-Yang, Lee Se-Hoon, Choi Murim

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP) allows estimation of clonal dynamics and documentation of somatic mutations in the hematopoietic system. Recent studies utilizing large cohorts of the general population and patients have revealed significant associations of CHIP burden with age and disease status, including in cancer and chronic diseases. An increasing number of cancer patients are treated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39641768
DOI: 10.7554/eLife.96951
PMCID: PMC11623926

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