Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Genome-wide associations with metabolic syndrome among UK Biobank participants reporting use of second-generation antipsychotics.

Pharmacotherapy - 1 Aug 2025

Rouby Nihal El, Owusu-Obeng Aniwaa, Preuss Michael, Lee Simon, Shi Mingjian, Lape Michael, Martin Lisa J, Namjou-Khales Bahram, Kottyan Leah C, Van Driest Sara L, Mosley Jonathan D, DelBello Melissa P

Abstract excerpt

OBJECTIVES: Second-generation antipsychotic (SGA) medications are frequently prescribed for mental health conditions; however, they are associated with an increased risk of metabolic syndrome (MetS). We aimed to identify genetic associations of SGA-associated MetS (SGA-MetS) using genome-wide approaches within the UK Biobank. We also set out to evaluate if genetically predicted obesity is associated with an...

Topics

Humans
Metabolic Syndrome
Genome-Wide Association Study
Antipsychotic Agents
Female
Male
United Kingdom
Middle Aged
Biological Specimen Banks
Cross-Sectional Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Body Mass Index

Obesity

Aged

Adult

UK Biobank

Source

Open in PubMed Open full text

Identifiers

PMID: 40762455
DOI: 10.1002/phar.70041
PMCID: PMC12340748

Genes

CHD2
CSMD1
PTPRD
RBFOX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide associations with metabolic syndrome among UK Biobank participants reporting use of second-generation antipsychotics.PMID 40762455Read ↗

Genome Wide Association Study (GWAS) Identifies Novel Genetic Loci for Second-Generation Antipsychotics (SGA)-Induced Metabolic Syndrome (MetS).Semantic proximity Read ↗

Genetic predisposition and antipsychotic treatment effect on metabolic syndrome in schizophrenia: a ten-year follow-up study using the Estonian BiobankSemantic proximity Read ↗

A systematic review of genetic variants associated with metabolic syndrome in patients with schizophrenia.Semantic proximity Read ↗

Pharmacogenetic study of antipsychotic–induced lipid and BMI changes in Chinese schizophrenia patients: A Genome-Wide Association StudySemantic proximity Read ↗

Identifying genetic contributions of 6q21 loci and PPAR pathway to antipsychotic-induced metabolic syndrome: a Sex-Stratified Multi-Omics study.Semantic proximity Read ↗

Cross-population validation of European GWAS loci for metabolic syndrome in Chinese schizophrenia.Semantic proximity Read ↗

Genetic evidence for the causal relations between metabolic syndrome and psychiatric disorders: a Mendelian randomization studySemantic proximity Read ↗

Pharmacogenetic Study of Antipsychotic-Induced Lipid and BMI Changes in Chinese Schizophrenia Patients: A Genome-Wide Association StudySemantic proximity Read ↗

Cardiometabolic risk and the MTHFR C677T variant in children treated with second-generation antipsychotics.Semantic proximity Read ↗

Polygenic risk scores analyses of psychiatric and metabolic traits with antipsychotic-induced weight gain in schizophrenia: an exploratory study.Semantic proximity Read ↗

Sex differences in shared genetic determinants between severe mental disorders and metabolic traits.Semantic proximity Read ↗

Genomic and transcriptomic insights into antipsychotic-induced changes in total cholesterol and body mass index in a multi-ancestry cohort of the US veteransSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.