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Article

Genome-wide associations with metabolic syndrome among UK Biobank participants reporting use of second-generation antipsychotics.

Pharmacotherapy - 1 Aug 2025

Rouby Nihal El, Owusu-Obeng Aniwaa, Preuss Michael, Lee Simon, Shi Mingjian, Lape Michael, Martin Lisa J, Namjou-Khales Bahram, Kottyan Leah C, Van Driest Sara L, Mosley Jonathan D, DelBello Melissa P

Abstract excerpt

OBJECTIVES: Second-generation antipsychotic (SGA) medications are frequently prescribed for mental health conditions; however, they are associated with an increased risk of metabolic syndrome (MetS). We aimed to identify genetic associations of SGA-associated MetS (SGA-MetS) using genome-wide approaches within the UK Biobank. We also set out to evaluate if genetically predicted obesity is associated with an...

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Identifiers

PMID: 40762455
DOI: 10.1002/phar.70041
PMCID: PMC12340748

Genes

CHD2
CSMD1
PTPRD
RBFOX1

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