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Article

Loss of peptidase D binding restores the tumor suppressor functions of oncogenic p53 mutants.

Communications biology - 8 Dec 2021

Yang Lu, Li Yun, Bhattacharya Arup, Zhang Yuesheng

Abstract excerpt

Tumor suppressor p53, a critical regulator of cell fate, is frequently mutated in cancer. Mutation of p53 abolishes its tumor-suppressing functions or endows oncogenic functions. We recently found that p53 binds via its proline-rich domain to peptidase D (PEPD) and is activated when the binding is disrupted. The proline-rich domain in p53 is rarely mutated. Here, we show that oncogenic p53 mutants closely...

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Identifiers

PMID: 34880421
DOI: 10.1038/s42003-021-02880-x
PMCID: PMC8655031

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