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The same but different: impact of animal facility sanitary status on a transgenic mouse model of Alzheimer’s disease

17 Apr 2025

Abstract excerpt

The gut-brain axis has emerged as a key player in the regulation of brain function and cognitive health. Gut microbiota dysbiosis has been observed in preclinical models of Alzheimer's disease and patients. Manipulating the composition of the gut microbiota enhances or delays neuropathology and cognitive deficits in mouse models. Accordingly, the health status of the animal facility may strongly influence these...

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PMID: 40243365
DOI: 10.1128/mbio.04001-24

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