Article
Strand-specific postreplicative processing of mammalian telomeres.
Science (New York, N.Y.) - 28 Sept 2001
Bailey S M, Cornforth M N, Kurimasa A, Chen D J, Goodwin E H
Abstract excerpt
Telomeres are specialized nucleoprotein structures that stabilize the ends of linear eukaryotic chromosomes. In mammalian cells, abrogation of telomeric repeat binding factor TRF2 or DNA-dependent protein kinase (DNA-PK) activity causes end-to-end chromosomal fusion, thus establishing an essential role for these proteins in telomere function. Here we show that TRF2-mediated end-capping occurs after telomere...
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