Inflammatory Biomarkers and Risk of Schizophrenia: A 2-Sample Mendelian Randomization Study.

doi:10.1001/jamapsychiatry.2017.3191

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Article

Inflammatory Biomarkers and Risk of Schizophrenia: A 2-Sample Mendelian Randomization Study.

JAMA psychiatry - 1 Dec 2017

Hartwig Fernando Pires, Borges Maria Carolina, Horta Bernardo Lessa, Bowden Jack, Davey Smith George

Abstract excerpt

Importance: Positive associations between inflammatory biomarkers and risk of psychiatric disorders, including schizophrenia, have been reported in observational studies. However, conventional observational studies are prone to bias, such as reverse causation and residual confounding, thus limiting our understanding of the effect (if any) of inflammatory biomarkers on schizophrenia risk. Objective: To evaluate...

Topics

Adult
Aged
Biomarkers
C-Reactive Protein
Female
Genetic Association Studies
Genetic Predisposition to Disease
Genetic Variation
Genome-Wide Association Study
Humans
Inflammation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interleukin 1 Receptor Antagonist Protein

Male

Mendelian Randomization Analysis

Middle Aged

Protective Factors

Receptors, Interleukin-6

Schizophrenia

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Identifiers

PMID: 29094161
DOI: 10.1001/jamapsychiatry.2017.3191
PMCID: PMC6583386

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