Genetic predisposition to inflammation and psychopathology: A transdiagnostic network analysis.

doi:10.1016/j.jad.2026.121424

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Genetic predisposition to inflammation and psychopathology: A transdiagnostic network analysis.

Journal of affective disorders - 15 Jun 2026

Usemann Paula Lea, David Friederike S, Brosch Katharina, Stein Frederike, Wroblewski Adrian, Thomas-Odenthal Florian, Teutenberg Lea, Pfarr Julia-Katharina, Evermann Ulrika, Flinkenflügel Kira, Meinert Susanne, Thiel Katharina, Winter Alexandra, Hahn Tim, Melzer Nico, Rietschel Marcella, Witt Stephanie H, Andlauer Till F M, Jamalabadi Hamidreza, Jansen Andreas, Straube Benjamin, Nöthen Markus M, Forstner Andreas J, Nenadić Igor, Dannlowski Udo, Kircher Tilo, Alexander Nina

Abstract excerpt

Although low-grade inflammatory processes have traditionally been studied in affective disorders, they are increasingly recognized as relevant across diagnostic categories. Genetic predisposition and environmental exposures such as childhood trauma (CT) may influence inflammation and shape vulnerability to psychopathology. Understanding how genetic predisposition for inflammation relates to specific symptom...

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PMID: 41713602
DOI: 10.1016/j.jad.2026.121424

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