Recombinant polymeric IgG: an approach to engineering more potent antibodies.

doi:10.1038/nbt0794-683

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Article

Recombinant polymeric IgG: an approach to engineering more potent antibodies.

Bio/technology (Nature Publishing Company) - 1 Jul 1994

Smith R I, Morrison S L

Abstract excerpt

IgM and IgG are the only classes of immunoglobulin capable of initiating the classical complement cascade. IgM, however, fixes complement much more effectively than IgG making it a more attractive Fc for some immunotherapeutic strategies. IgG, on the other hand, triggers additional effector funct...

Topics

Animals
Complement C1
Complement C1q
Genetic Engineering
Half-Life
Hemolysis
Humans
Immunoglobulin G
Immunoglobulin M
Mice
Mice, Inbred BALB C
Mutation
Receptors, Fc
Recombinant Proteins

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