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Article

Recombinant polymeric IgG: an approach to engineering more potent antibodies.

Bio/technology (Nature Publishing Company) - 1 Jul 1994

Smith R I, Morrison S L

Abstract excerpt

IgM and IgG are the only classes of immunoglobulin capable of initiating the classical complement cascade. IgM, however, fixes complement much more effectively than IgG making it a more attractive Fc for some immunotherapeutic strategies. IgG, on the other hand, triggers additional effector functions mediated through gamma specific Fc receptors. Using a generalizable technique we have produced IgM-like polymers...

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PMID: 7764912
DOI: 10.1038/nbt0794-683

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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