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Two chemotherapeutic agents expand stem-like CD62L+CD8+ T cells in antitumor immune responses

1 Apr 2025

Abstract excerpt

Introduction Recent findings reveal that the precursors of exhausted CD8 + T (CD8 + Tpex) cells possess stem-like signatures in tumor immunity, which originate from tumor draining lymph node (TdLN)-derived tumor-specific memory (CD8 + T TSM ) cells. Both of these T subsets can be collectively referred to as stem-like CD8 + T cells, which demonstrate robust self-renewal ability and can proliferate and...

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PMID: 40236705
DOI: 10.3389/fimmu.2025.1533857

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