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Article

CXCL1 and CXCL8: Reliable and feasible biomarkers differentiating intrapulmonary metastasis from multiple primary neoplasms in non-small cell lung cancers.

Cancer biomarkers : section A of Disease markers - 1 Apr 2025

Liu Ao, Sun Tianlin, Qiu Tong, Chen Yunqing, Qi Huiyang, Du Wenxing, Wu Zhe, Huang Zhan, Su Wenqing, Zhu Changbin, Jiao Wenjie

Abstract excerpt

ObjectiveIn NSCLC, the main approach to differentiate between intrapulmonary metastases (IPM) and multiple primary lung cancer (MPLC) is to integrate histopathological and genomic information. Here, we identified viable biomarkers that can distinguish IPM from MPLC by integrating comprehensive genomic profiling (CGP) and targeted RNA sequencing.MethodsWe retrospectively collected tissues from at least two lesions...

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Share to Biomarkers, Tumor
Share to Carcinoma, Non-Small-Cell Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemokine CXCL1

Share to Diagnosis, Differential

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Share to Interleukin-8

Share to Lung Neoplasms

Share to Neoplasms, Multiple Primary

Source

Open in PubMed Open full text

Identifiers

PMID: 40235059
DOI: 10.1177/18758592241308730
PMCID: PMC12288606

Genes

CXCL1
CXCL8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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