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Single‐cell dissection reveals immunosuppressive F13A1+ macrophage as a hallmark for multiple primary lung cancers

27 Nov 2024

Abstract excerpt

BACKGROUND: The increasing prevalence of multiple primarylung cancers (MPLCs) presents challenges to current diagnostic and clinicalmanagement approaches. However, the molecular mechanisms driving MPLCdevelopment and distinguishing it from solitary primary lung cancers (SPLCs)remain largely unexplored. METHODS: We performed a comparative single-cell RNAsequencing (scRNA-seq) analysis on tumour and adjacent...

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PMID: 39601163
DOI: 10.1002/ctm2.70091

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