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Article

Colon cancer exosome-associated HSP90B1 initiates pre-metastatic niche formation in the liver by polarizing M1 macrophage into M2 phenotype.

Biology direct - 15 Apr 2025

Li ShuJie, Fu Xue, Ning Deng, Liu QiuMeng, Zhao JunFang, Cheng Qi, Chen XiaoPing, Jiang Li

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) frequently metastasizes to the liver, worsening patient outcomes. The formation of a pre-metastatic niche (PMN) is essential for this process, but how the primary colon tumor orchestrates the PMN formation remains unclear. METHODS: This study investigated the role of CRC-derived exosomes using CT-26 murine colon carcinoma cells. The effects of these exosomes on immune cells,...

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Share to CD8-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40234961
DOI: 10.1186/s13062-025-00623-0
PMCID: PMC12001560

Genes

HSP90B1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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