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Article

The TESTBREAST journey: Revisiting the importance of early detection by frequent screening of women at high risk of breast cancer.

International journal of cancer - 15 Aug 2025

Andour Layla, Hagenaars Sophie C, Vangangelt Kiki, Aalberts Janneke, Rebattu Valerie, van der Meer Dorien M A Berends, Kranenbarg Elma Meershoek-Klein, Gaarenstroom Katja N, van Asperen Christi J, Tollenaar Rob A E M, Mesker Wilma E

Abstract excerpt

Women with an inherited pathogenic variant (PV) in a breast cancer (BC) susceptibility gene, or familial predisposition (FP) have an increased risk to develop BC. There is a need for improvement of screening methods due to interval cancers and radiation exposure. The aim of the TESTBREAST study is to develop a blood test suitable for early diagnosis. Here, the clinical composition of participants is provided....

Topics

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Aged
Biomarkers, Tumor
BRCA1 Protein
BRCA2 Protein
Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Early Detection of Cancer

Follow-Up Studies

Genetic Predisposition to Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 40232159
DOI: 10.1002/ijc.35444
PMCID: PMC12178100

Genes

BRCA1
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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