Article
Impact of Population-Based Pathogenic Variant Testing on Risk-Based Breast Screening Recommendations: A Secondary Analysis of the WISDOM Study.
JAMA oncology - 1 Aug 2026
Shieh Yiwey, Heise Rachel S, Madlensky Lisa, Sabacan Leah P, Soto Irene A, Fiscalini Allison S, Ross Katherine, Goodman Deborah, Blanco Amie, Brain Susie, Heditsian Diane Marie, Moya Jackelyn, Fergus Kirkpatrick B, Olopade Olufunmilayo I, Scheuner Maren T, Eklund Martin, Ziv Elad, Tice Jeffrey A, van 't Veer Laura, Esserman Laura J
Abstract excerpt
Importance: Risk-based breast cancer screening has emerged as a viable alternative to annual mammography. To guide implementation, knowledge is needed on the contribution of testing for pathogenic variants (PVs) beyond clinical risk factors and common genetic variants for population-based risk stratification. Objective: To evaluate how many PV carriers in a risk-based breast cancer screening trial would have been...
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