The multifaceted roles of the transcriptional coactivator TAZ in extravillous trophoblast development of the human placenta

Abstract excerpt

Insights into the molecular processes that drive early development of the human placenta is crucial for our understanding of pregnancy complications such as preeclampsia and fetal growth restriction, since defects in maturation of its epithelial cell, the trophoblast, have been detected in the severe forms of these diseases. However, key regulators specifying the differentiated trophoblast subtypes of the...

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