Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dysregulation of MYBL2 impairs extravillous trophoblast lineage development and function, contributing to recurrent spontaneous abortion

28 Apr 2025

Abstract excerpt

Recurrent spontaneous abortion (RSA) is a pregnancy-related condition characterized by a complex etiology. While placental trophoblast dysfunction is strongly associated with the development and progression of RSA, the underlying molecular mechanisms remain poorly understood. In this study, we observed a significant decrease in the expression of MYB Proto-Oncogene Like 2 (MYBL2) in the villous tissue of patients...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Kruppel-like factors research
Share to Pregnancy and preeclampsia studies
Share to Renal and related cancers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40294258
DOI: 10.1073/pnas.2421653122

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dysregulation of MYBL2 impairs extravillous trophoblast lineage development and function, contributing to recurrent spontaneous abortionPMID 40294258Read ↗

The multifaceted roles of the transcriptional coactivator TAZ in extravillous trophoblast development of the human placentaSemantic proximity Read ↗

CRY2 suppresses trophoblast migration and invasion in recurrent spontaneous abortionSemantic proximity Read ↗

Single-cell and spatial transcriptomics reveal alterations in trophoblasts at invasion sites and disturbed myometrial immune microenvironment in placenta accreta spectrum disordersSemantic proximity Read ↗

miR-146b-5p downregulates IRAK1 and ADAM19 to suppress trophoblast proliferation, invasion, and migration in miscarriageSemantic proximity Read ↗

Single-cell transcriptional profiling reveals cellular and molecular divergence in human maternal–fetal interfaceSemantic proximity Read ↗

PLAC8, a new marker for human interstitial extravillous trophoblast cells, promotes their invasion and migrationSemantic proximity Read ↗

Regionally distinct trophoblast regulate barrier function and invasion in the human placentaSemantic proximity Read ↗

Trophoblast Differentiation: Mechanisms and Implications for Pregnancy ComplicationsSemantic proximity Read ↗

Circular RNA PUM1 (CircPUM1) attenuates trophoblast cell dysfunction and inflammation in recurrent spontaneous abortion via the MicroRNA-30a-5p (miR-30a-5p)/JUNB axisSemantic proximity Read ↗

Hippo signaling cofactor, WWTR1, at the crossroads of human trophoblast progenitor self-renewal and differentiationSemantic proximity Read ↗

VGLL1 contributes to both the transcriptome and epigenome of the developing trophoblast compartmentSemantic proximity Read ↗

tRF-5028c disrupts trophoblast function in recurrent spontaneous abortion by inhibiting CRKL-mediated Rap1 signaling pathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.