Small molecules direct the generation of ameloblast-like cells from human embryonic stem cells

doi:10.1186/s13287-025-04294-6

Article

Small molecules direct the generation of ameloblast-like cells from human embryonic stem cells

12 Apr 2025

Abstract excerpt

BACKGROUND: Ameloblasts present a promising avenue for the investigation of enamel and tooth regeneration. Previous protocols for directing the differentiation of human embryonic stem cells (hESCs) into dental epithelial (DE) cells involving the need for additional cells, conditional medium, and the use of costly cytokines. Importantly, ameloblasts have not been generated from hESCs in previous studies. Hence, we...

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