Designed Soluble Notch Agonist Drives Human Ameloblast Maturation for Tooth Regeneration

Abstract excerpt

<h4>Summary</h4> Enamel, the hardest material in the human body, is required to protect our living organ, tooth. However, over 90% of adults have lost or damaged enamel and cannot regenerate the protective structure due to lack of enamel producing cells, ameloblasts. iPSC derived mature Ameloblasts (iAM) have promise in future regenerative dentistry. Today it is not known why iAM maturation requires intimate cont...

Topics

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• Anodontia
• Bone and Dental Protein Studies
• Bone Morphogenetic Proteins
• Epithelial-Mesenchymal Transition
• Fibroblast Growth Factors
• Mutation
• Regeneration
• Signal Transduction

Identifiers and source

Literature Corpus work

39ebaa13-9c59-5c9c-9096-38f44027e17a

DOI

10.1101/2025.04.03.646929