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Article

Allele-specific N-glycosylation delays human surfactant protein B secretion in vitro and associates with decreased protein levels in vivo.

Pediatric research - 1 Dec 2013

Taponen Saija, Huusko Johanna M, Petäjä-Repo Ulla E, Paananen Reija, Guttentag Susan H, Hallman Mikko, Haataja Ritva

Abstract excerpt

BACKGROUND: Surfactant protein B (SP-B) is essential for normal lung function, and decreased concentrations of SP-B have a deleterious effect on pulmonary outcome. SP-B levels may correlate with variations in the encoding gene (SFTPB). SFTPB single-nucleotide polymorphism Ile131Thr affects proSP-B N-glycosylation in humans and the glycosylated Thr variant associates with pulmonary diseases. METHODS: We analyzed...

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PMID: 24002332
DOI: 10.1038/pr.2013.151

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SFTPB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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