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Article

Upregulated osterix promotes invasion and bone metastasis and predicts for a poor prognosis in breast cancer

10 Jan 2019

Abstract excerpt

Approximately 70% of patients with advanced breast cancer develop bone metastases, accompanied by complications, such as bone pain, fracture, and hypercalcemia. However, our understanding of the molecular mechanisms that govern this process remains fragmentary. Osterix (Osx) is a zinc finger-containing transcription factor essential for osteoblast differentiation and bone formation. Here, we identified the...

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PMID: 30631043
DOI: 10.1038/s41419-018-1269-3

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