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Article

Causal effects of Annexin A1 and Annexin A2 on ischemic stroke and its subtypes: A two-sample Mendelian randomization study.

Journal of cardiology - 1 Sept 2025

Jiang Minglan, Sun Lulu, Jia Yiming, Ren Xiao, Han Longyang, Zhu Zhengbao, Zheng Xiaowei

Abstract excerpt

BACKGROUND: Preclinical studies have suggested that Annexin A1 and Annexin A2 act as anti-inflammatory agents, slowing the progression of atherosclerosis and further potentially reducing the risk of ischemic stroke. Since the causality of Annexins and ischemic stroke remains uncertain, this study aimed to investigate the causal effects of both using a two-sample Mendelian randomization (MR) method. METHODS: The...

Read the complete abstract on PubMed

Topics

Humans
Annexin A2
Mendelian Randomization Analysis
Ischemic Stroke
Genome-Wide Association Study
Annexin A1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Male

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Identifiers

PMID: 40187529
DOI: 10.1016/j.jjcc.2025.03.019

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