Loss of conserved long non-coding RNA MIR503HG leads to altered NOTCH pathway signalling and left ventricular non-compaction cardiomyopathy.

doi:10.1093/cvr/cvaf043

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Article

Loss of conserved long non-coding RNA MIR503HG leads to altered NOTCH pathway signalling and left ventricular non-compaction cardiomyopathy.

Cardiovascular research - 8 Jul 2025

Monteiro João P, Saha Diptarka, Spiroski Ana-Mishel, Mahesh Saiba, Kaltzis Peter, Nadavallil Abhijit, Janbandhu Vaibhao, Murray Nicholas J, Severi Francesco, De Pace Azzurra Laura, Sánchez-Esteban Sandra, Rodor Julie, Beqqali Abdelaziz, Bennett Matthew, Stewart Kevin, Thomson Adrian, Hadoke Patrick W F, Markose Dyana, Wilson-Kanamori John R, Henderson Neil C, O'Carroll Dónal, Quertermous Thomas, Harvey Richard P, Del Monte-Nieto Gonzalo, Baker Andrew H

Abstract excerpt

AIMS: The highly conserved long non-coding RNA (lncRNA) MIR505HG has been primarily recognized as a precursor for microRNAs (miR)-424 and miR-503. However, studies have since demonstrated that MIR503HG has distinct functions from its associated miRNAs, playing important roles in cell proliferation, invasion, apoptosis, and differentiation. While these miRNAs are known to influence cardiomyocyte differentiation,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40183391
DOI: 10.1093/cvr/cvaf043
PMCID: PMC12236064

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