Article
Structural and mutational analyses of dipeptidyl peptidase 11 from Porphyromonas gingivalis reveal the molecular basis for strict substrate specificity.
Scientific reports - 9 Jun 2015
Sakamoto Yasumitsu, Suzuki Yoshiyuki, Iizuka Ippei, Tateoka Chika, Roppongi Saori, Fujimoto Mayu, Inaka Koji, Tanaka Hiroaki, Yamada Mitsugu, Ohta Kazunori, Gouda Hiroaki, Nonaka Takamasa, Ogasawara Wataru, Tanaka Nobutada
Abstract excerpt
The dipeptidyl peptidase 11 from Porphyromonas gingivalis (PgDPP11) belongs to the S46 family of serine peptidases and preferentially cleaves substrates with Asp/Glu at the P1 position. The molecular mechanism underlying the substrate specificity of PgDPP11, however, is unknown. Here, we report the crystal structure of PgDPP11. The enzyme contains a catalytic domain with a typical double β-barrel fold and a...
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