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Article

Rare genetic variants in PKD1 and SMAD2 are associated with intracranial aneurysms in the general population.

International journal of stroke : official journal of the International Stroke Society - 1 Oct 2025

Wolters Bibi M, Bakker Mark K, Rannikmäe Kristiina, Hop Paul J, Ruigrok Ynte M

Abstract excerpt

INTRODUCTION: Family studies identified several rare genetic risk variants for intracranial aneurysms (IAs) and aneurysmal subarachnoid hemorrhage (ASAH). In addition, certain monogenic disorders caused by rare penetrant genetic variants predispose individuals to IA and ASAH. We investigated the effect of these variants on IA and ASAH in the general population. PATIENTS AND METHODS: We tested the association...

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Source

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Identifiers

PMID: 40172005
DOI: 10.1177/17474930251334501
PMCID: PMC12446701

Genes

PKD1
SMAD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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